oh boyyy. This is a doozy.
- Thread starter bamagirl26
- Start date
Mold Is Becoming a Costly New Headache for Homebuilders — D.R. Horton and Lennar Are Paying the Price
Mold-related lawsuits are adding to the financial pressure on major U.S. home builders as homeowners allege construction defects caused mold growth and health problems. The number of lawsuits against home builders has been rising as homeowners blame construction problems for...
finance.yahoo.com
bamagirl26
Explorer
It's everywhere!! But for real though, my point was that the FDA is stopping shipments of ingredients coming out of these manufacturing facilities altogether- and they don't even need to crack open a box to do it. My guess is that this could tie into those gross HYALO Vials people mentioned last week. Sure, there will always be some workaround, but seriously, come on China. Get the factory clean!
kakiebean
Explorer
AND....this is exactly the reason filtering your peptides matters. 
Honestly, when it comes to supply chain risk, a facility making APIs that FDA inspectors actually visit would rank pretty low on my list of concerns.
And regarding problems, even here in the US, my guess is it resembles PPM.. sometimes ignorance really is bliss..
What Happens When You Ingest Mold
- Stomach Breakdown: Mold cells and a lot of the compounds tied to them get broken down on their own by the acids and digestive enzymes in your stomach.
- Mild Reaction: For the majority of healthy individuals, the only thing they notice is a bad taste that's earthy or like dirt.
- Gastrointestinal Upset: Occasionally, people who are sensitive, or cases where a lot of contaminated food was eaten, can bring on minor stomach trouble, queasiness, or cramping. [1, 2, 3]
When Mold Is Dangerous
- Mycotoxins: A few types of mold generate poisonous substances known as mycotoxins. When they show up in large quantities on particular grains, nuts, or food that has gone bad, the result can be serious poisoning, sharp stomach pain, or health problems down the road. [1, 2]
- Food Safety Rule: The USDA Food Safety and Inspection Service says that any food with a lot of moisture (think lunch meats, cooked leftovers, soft cheeses, and baked goods) should be thrown out right away once mold is visible, since mold is able to work its way beneath the surface.
It strikes me as awfully convenient that the FDA just so happened to identify a substance that is extremely hard — and expensive — to test for with any accuracy, that wouldn't be caught by filtration, and that grows so slowly you couldn't spot any visible change or any shift in pH until long after the vial had already gone bad...
And I'm saying this as a person who has run quality audits at labs and production sites and has genuinely "seen some shit".
And I'm saying this as a person who has run quality audits at labs and production sites and has genuinely "seen some shit".
kakiebean
Explorer
That checks out. Mycotoxins are tiny, low-molecular-weight chemical compounds — usually below 500–1,000 Daltons — while a typical 0.22 µm syringe filter only catches bigger physical particles, bacteria, and fungal spores. Getting rid of them takes solid-phase extraction (SPE) or immunoaffinity columns. Still, does anyone actually want all the gunk that a filter CAN catch?
Yet that facility holds a license from the Chinese government to produce pharmaceutical active ingredients.
I'm confident the shadowy, unregulated basement operations run by Chinese criminals supplying the black market are far more diligent about their customers' wellbeing....
bamagirl26
Explorer
I couldn't agree more!!!!! There's no question our labs are cleaner!
PAPoots
Explorer
It brings to mind that motivational speaker — possibly Tony Robbins — who ran an event where attendees walked over hot coals, and a number of them ended up in the hospital with burns.Calm Logic said:
Two People Almost Died at RAADfest. We Went to the Experts.
Two people nearly died, and several more sought treatment, after receiving peptide injections at the last RAADfest in Las Vegas.lifespan.io
Click to expand...
So much for "What happens in Vegas stays in Vegas"
Flash-BCR
Explorer
Situations like this are exactly why I value the subforums covering CJC, Mots, Tesa and similar peptides — you can gather info on them before giving any a try. Mots isn't my thing (so far)... but CJC w IPA is on its way to me, and I already have Tesa, and before I ever test either one I'll be doing thorough reading here and on other places. On top of that, I plan to order an epi-pen beforehand...
Some molds generate chemicals known as mycotoxins. While the article described mold issues and other production problems, it never stated that the products underwent mycotoxin testing or that contamination was confirmed in any product. Were mycotoxins to have gotten into the product, one could reasonably expect that neither freeze-drying nor filtering would lower or remove such a toxin. Detecting this particular byproduct would require testing specifically designed to find mold-produced mycotoxins; standard microbial testing by itself would not determine whether mycotoxins were there.
Browneyes26
Explorer
That is just how things work in this world…
FartfulCodger
Explorer
Bacteria, endotoxins, and other contaminants, correct? Things that in many cases your stomach would neutralize. I doubt anyone knows the risk rates, and there are a lot of variables involved.
When a substance is injected subcutaneously (SC), the tissue architecture changes how fluids move and pushes contaminants into the lymphatic system, which gives it a clear protective edge over intravenous (IV) or intramuscular (IM) delivery against bacteria and endotoxins. [1, 2]
1. Physical filtering and delayed uptake
- Blood vessel density: Fat tissue and a fibrous matrix make up the subcutaneous layer. It has much less vasculature than muscle (IM) and, unlike IV, no direct route into the bloodstream. [1, 2]
- The "depot" effect: This low vascularity means injected fluid collects temporarily as a deposit or "depot". The dense extracellular matrix (collagen and hyaluronan) works as a physical sieve, slowing the movement of large foreign particles. [1, 2]
- Size cutoff: Small molecules (<16 kDa) can enter blood capillaries directly. But whole bacteria (typically 1,000–2,000 nm) and large endotoxin/lipopolysaccharide aggregates are too big to cross blood vessel walls. [1, 2]
- The lymphatic route: Instead, they must enter the very permeable, open-ended capillaries of the lymphatic system. [1, 2]
- The checkpoint: Lymph fluid has to move through a series of draining lymph nodes before it reaches the general bloodstream. These nodes serve as dedicated security checkpoints loaded with specialized immune cells (macrophages and dendritic cells). [1, 2]
- Neutralization: Local macrophages actively phagocytize (engulf) bacteria and endotoxins as they move through the lymphatic network. Also, the slow transit gives blood-derived inhibitory proteins in lymph fluid time to partially inactivate endotoxins before they reach central circulation. [1, 2, 3]
[th]Injection Route[/th][th]Bloodstream Access[/th][th]Systemic Shock/Sepsis Risk[/th][th]Primary Defense Mechanism[/th]
[td]Intravenous (IV)[/td][td]Immediate[/td][td]Highest[/td][td]None. Contaminants instantly bypass all local tissue and lymphatic filters.[/td]
[td]Intramuscular (IM)[/td][td]Rapid[/td][td]Moderate[/td][td]Highly vascularized muscle allows quick absorption directly into blood capillaries.[/td]
[td]Subcutaneous (SC)[/td][td]Delayed/Indirect[/td][td]Lowest[/td][td]Forced transit through the lymphatic system, exposing pathogens to lymph node filtration and immune destruction.[/td]
FartfulCodger
Explorer
Nobody would really dispute that reply, I figure. According to A.I., injecting a toxin under the skin carries far more risk than simply swallowing it. Eating it versus pinning it—that's the only thing I ever brought up.
Before they can be absorbed, stomach acids and other enzymes knock out plenty of bacteria and their toxins. On top of that, you get the vomiting reflex as an extra safeguard.
Someone must have looked into how many severe infections and/or deaths result from subcutaneous infections. Given how worried people are about this, my assumption is that they've researched the fatalities or serious illnesses tied to sub q injections.
myboysherman
Explorer
I've put a fair amount of effort into looking this up, though not a huge amount. What I was after was sepsis or blood infections resulting from SQ. Along the way I came across the term "poppers," which apparently refers to some kind of degenerate drug habit and isn't really on point.
Given how many people reuse pen needles for repeated insulin injections, maybe someone with medical training could dig around and actually turn up something useful. If this were a significant concern, I'd expect at minimum some case studies beyond this oddball junkie thing.
I just reconstituted my latest reta, and I'm thinking about skipping filtering, what with the bac testing and, well, all of this.