New to This: PCOS/PMOS with Insulin Resistance — Looking for Guidance

Hi everyone! Around 3 years back, I received diagnoses of Hyperinsulinemia (insulin resistance) along with PCOS/PMOS, and I've now made the decision to pursue this path for managing it. Zepbound was what I used for 2 months, and I really liked it, but then my insurance cut off coverage, and trying to figure all of this out left me feeling overwhelmed. I switched to wegovy, and I've disliked it intensely; I experienced muscle loss, significant hair shedding, and stubborn acne on my shoulders/back that won't go away. For 3 years I've been on metformin at 1500mg, and it seems to help a little with insulin sensitivity. Spironolactone has been something I've cycled on and off at every dose for at least 6 years, and I'm ready to try something different. My goal is to drop no more than 30lbs, and what I really want is radiant, healthy skin and hair. I've been looking into Tirz or Reta for weight management, plus GHK-Cu & KPV for skin and hair health. Learning about this kind of thing on my own is hard for me, but I'm putting in my absolute best effort. Any and all suggestions or input to help me dive fully into this journey would be so appreciated. <3

Hello! I'm not sure whether this is something you've possibly come across before or perhaps already used, but do you know about pioglitazone or the other medications in the TZD class? In case these are new to you: this drug class consists of highly potent insulin sensitizers. They redirect adipose storage toward sWAT rather than VAT, favoring the lower body and particularly gluteofemoral sWAT. On top of that, they enhance the general metabolic performance of sWAT.

I've come across reports of individuals stacking low-dose retatrutide with pioglitazone for body composition purposes, and I'll likely give that a try myself before long.

MalibuBarbie said:


Hello all! I was diagnosed with Hyperinsulinemia (insulin resistance) & PCOS/PMOS about 3 years ago & have finally decided this is the route I want to take for managing that. I was on zepbound for 2 months & I loved it, but my insurance stopped coverage & I got overwhelmed trying to navigate all this. I ended up getting on wegovy & I have hated it; I lost muscle & a lot of hair as well as permanent stubborn shoulder/back acne. I have been taking 1500mg of metformin for 3 years now & I feel like it helps slightly with my insulin sensitivity. I have been on & off of Spironolactone at all doses for at least 6 years now, I’m ready for something new. Im wanting to lose max 30lbs, & im desperately wanting glowy healthy skin/hair. I have considered Tirz or Reta for weight management & GHK-Cu & KPV for skin/hair health. I struggle with learning independently about this type of stuff, but I’m trying my absolute hardest. I would love any & all suggestions or inputs to help me fully dive into this journey. <3

Click to expand...

Click to expand...

has mots-c/aicar ever crossed your mind? these are AMPK activators, similar to metformin, except they don't cut ATP production in order to work. they're believed to assist with insulin resistance.

xenopittan said:

Hello! I'm not sure whether this is something you've possibly come across before or perhaps already used, but do you know about pioglitazone or the other medications in the TZD class? In case these are new to you: this drug class consists of highly potent insulin sensitizers. They redirect adipose storage toward sWAT rather than VAT, favoring the lower body and particularly gluteofemoral sWAT. On top of that, they enhance the general metabolic performance of sWAT.

I've come across reports of individuals stacking low-dose retatrutide with pioglitazone for body composition purposes, and I'll likely give that a try myself before long.

Click to expand...

This is all new to me, though it seems worth investigating. The majority of my weight sits around my middle. If I don't deal with this soon, I worry my insulin resistance could progress to NAFLD.

Hi! We share the same form of PMOS, so hopefully the two of us can discover relief without spending a ton of money.

perperperpen said:

has mots-c/aicar ever crossed your mind? these are AMPK activators, similar to metformin, except they don't cut ATP production in order to work. they're believed to assist with insulin resistance.

Click to expand...

I haven't given them any thought. I know some people take mots-c, though that's as far as my looking into it went. I should probably dig deeper into that.