bogardbilla
Explorer
That matches my understanding: 2mg of the original Egrifta and 1.28mg of Egrifta WR deliver an equivalent quantity of Tesamorelin that the body absorbs.
Tesamorelin Added to Reta
- Thread starter Phatmax
- Start date
RadicalCrimson
Explorer
FWIW, titration isn't part of Tesa protocols, though it is for Isa, so I'm applying it to both:
On top of that, I've got a glucose monitor on, and for some reason my glucose keeps dropping lower and lower, so insulin resistance apparently isn't an issue, lol.
Right now I'm in the 1500 stage.
- 100/1000 for 0.5 weeks
- 133/1000 for 0.5 weeks
- 200/1500 for 2 weeks
- After that 266/2000. 300/2000 is a possibility.
On top of that, I've got a glucose monitor on, and for some reason my glucose keeps dropping lower and lower, so insulin resistance apparently isn't an issue, lol.
Right now I'm in the 1500 stage.
RadicalCrimson
Explorer
According to the FDA approval document I shared earlier:
- When fasting glucose hits 110, the options are returning to 1mg or moving to 2mg taken every 2 days
- Should IGF-1 hit 3 standard deviations (+3.0 Z-score?), stop completely.
RadicalCrimson
Explorer
Right, Subcutaneous Adipose Tissue (SAT) went up marginally (+2%), yet subjects at a 27 BMI (near my own) experienced a 1.4kg (3 pounds) drop in fat (largely trunk), plus a 1.7kg (almost 4 pounds) gain in lean mass, for a total delta of 3.1kg.
Put differently, the muscle they put on outweighed the fat they shed.
Numbers for obese individuals would likely look even stronger.
Count me in.
RadicalCrimson
Explorer
Keep in mind that this Phase 2 trial ran for just 12 weeks.
As for the Phase 3 trials, those lasted 52 weeks, though at the 26-week mark they pulled the nasty switcheroo with placebo (the placebo group switches to Tesa, half of the Tesa group switches to placebo, and the remaining half is the fortunate one that receives the full year).
The results from that extension are shown by the green line (T-T):
Should you discontinue Tesa at the 6-month point, you become the blue line (T-P).
Summary of Extension Phases of LIPO-010 and CTR-1011 - Clinical Review Report: Tesamorelin (Egrifta) - NCBI Bookshelf
As for the Phase 3 trials, those lasted 52 weeks, though at the 26-week mark they pulled the nasty switcheroo with placebo (the placebo group switches to Tesa, half of the Tesa group switches to placebo, and the remaining half is the fortunate one that receives the full year).
The results from that extension are shown by the green line (T-T):
Should you discontinue Tesa at the 6-month point, you become the blue line (T-P).
Summary of Extension Phases of LIPO-010 and CTR-1011 - Clinical Review Report: Tesamorelin (Egrifta) - NCBI Bookshelf
RadicalCrimson
Explorer
Keep in mind that every one of these participants is HIV-positive and has been on HIV treatment for years, and they kept using that treatment even after stopping TESA.
As far as I know, no official account has been given for why HIV medication leads to additional VAT.
Likely because no one enrolled in the trial that swapped those people over to placebo
As far as I know, no official account has been given for why HIV medication leads to additional VAT.
Likely because no one enrolled in the trial that swapped those people over to placebo
Derbyshire
Explorer
Appreciate the info. That Blue line is what concerns me the most. That said, if those individuals continued their HIV treatment—which is thought to be what drives the additional VAT—then a reversal seems very probable. It would be worth checking in people not on HIV meds to find out how that blue line would behave in that case. Based on what folks report about Tesa and the outcomes they achieve, does it look like Tesa should be chosen over CJC-1295 without DAC + IPA?
UpDownLeftRightAS*
Explorer
It strikes me as somewhat odd, as a side note, that this medication remains in production with a new 2025 formulation (beyond off-label usage), considering that the HIV treatments most linked to fat redistribution are especially the early protease inhibitors going back to the late ’80s and early ’90s.
Considering the experiences of patients in that period, frequently depending on experimental therapies carrying major side effects, it really highlights the progress science has made.
Based on what I’ve observed, among them certain summaries from Perplexity, current treatments are generally linked more to slight overall weight gain instead of the marked fat redistribution patterns tied to older regimens.
https://www.perplexity.ai/search/do-modern-hiv-drugs-still-caus-EYVrnphfRjqY.7n8AJjKXQ
Considering the experiences of patients in that period, frequently depending on experimental therapies carrying major side effects, it really highlights the progress science has made.
Based on what I’ve observed, among them certain summaries from Perplexity, current treatments are generally linked more to slight overall weight gain instead of the marked fat redistribution patterns tied to older regimens.
https://www.perplexity.ai/search/do-modern-hiv-drugs-still-caus-EYVrnphfRjqY.7n8AJjKXQ
Quatroskin
Explorer
How did you begin dosing, and what was the schedule — 5 days on with 2 days off, or daily?
RadicalCrimson
Explorer
Look at what I wrote earlier — it's been just 2 weeks since I began. I take it daily.
bogardbilla
Explorer
That is false.
Are you able to say whether you combine it with reta?
What are you aiming for with this — only building muscle, or dropping fat as well?
I came across a protocol that listed
Fasted at night
2mg tesa
200mcg cjc no dac and 200mcg ipa
Then fasted 200mcg ipa in the morning
Wondering whether that would be logical for fat loss alongside reta.
What do you think? @Calm Logic it would be nice if you could weigh in too.
UpDownLeftRightAS*
Explorer
From what I understand, the labeling doesn't mention needing a fasted state or a particular time of day. With GH/Sg's, timing matters more because they're so thoroughly researched, so it makes sense to optimize. My own dose goes in the morning right after waking, while fasted (usually just coffee plus some vital protein). Reta was the same story—it kept me too wired, so mornings became my only option.
chewonmysac
Explorer
Same routine here. Currently in my 2nd run of it. My 1st run was just 4 weeks because my math was off. Still noticed a reasonable drop in waist size. Now I'm going for 8 weeks, and I'm 3 weeks in. Zero rest days. Total will be 12 vials at 10 mg each. Once mixed, I keep it at room temp. Fingers crossed I'll be able to rock my mesh half-shirt this summer.
Taking Tesa and CJC simultaneously means they'll compete for the same receptors. Pairing either one with Ipa produces a 1+1=3 outcome, but combining them with each other only gives a 1+1=1.5 result lol. The overall approach could still be viable if you shifted your Tesa dose to the morning alongside your first Ipa dose—that's something I plan to test myself in about a month.
WYSiWYG
Explorer
After going through this thread and the info shared here, I'm now second-guessing whether to start the 2 kits that just arrived. My plan had been to stack Tesa with Reta to cut overall BF. Right now I've got a good grip on diet/nutrition and training - but after reading this, it feels like maybe that isn't the best move at the moment.
chewonmysac said:
Same routine here. Currently in my 2nd run of it. My 1st run was just 4 weeks because my math was off. Still noticed a reasonable drop in waist size. Now I'm going for 8 weeks, and I'm 3 weeks in. Zero rest days. Total will be 12 vials at 10 mg each. Once mixed, I keep it at room temp. Fingers crossed I'll be able to rock my mesh half-shirt this summer.
So is it possible to verify the test while it sits at room temperature?
chewonmysac
Explorer
For me it did the job, kept at room temp inside a cabinet. At 2mg per day, the vial was gone in 5 days. It performed just as expected. Since switching to HGH, the difference is far more obvious — my midsection has really gone flat and the side fat has melted away. 3iu per day. That's been going for 57 days now. Likely I'll pause it next month.boris said:
chewonmysac said:
Same routine here. Currently in my 2nd run of it. My 1st run was just 4 weeks because my math was off. Still noticed a reasonable drop in waist size. Now I'm going for 8 weeks, and I'm 3 weeks in. Zero rest days. Total will be 12 vials at 10 mg each. Once mixed, I keep it at room temp. Fingers crossed I'll be able to rock my mesh half-shirt this summer.
So is it possible to verify the test while it sits at room temperature?